Impact of Feeding Amino Acids on Reproduction

Studies over the last 2 decades clearly established the link between nutri on and fer lity in ruminants (Robinson et al., 2006; Wiltbank et al., 2006; Grummer et al., 2010; Santos et al., 2010; Cardoso et al., 2013; Drackley and Cardoso, 2014). Dietary changes can cause an immediate and rapid altera on in a range of humoral factors that can alter endocrine and metabolic signaling pathways crucial for reproducve func on (Boland et al., 2001; Diskin et al., 2003). Moreover, periconcep onal nutri onal environment in humans and other animals is cri cal for the longterm se ng of postnatal phenotype (Fleming et al., 2015). Restric ng the supply of B-vitamins and methionine during the periconcep onal period in sheep, e.g., resulted in adverse cardiometabolic health in postnatal off spring (Sinclair et al., 2007). Feeding female mice a low-protein diet during the preimplanta on period of pregnancy resulted in a reduc on in amino acid (AA) concentra on in uterine fl uid and serum and a endant changes in the AA profi le of the blastocyst (Eckert et al., 2012).